44 articles - From Friday Dec 16 2022 to Friday Dec 23 2022
Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…
meta-analyses and systematic reviews
| Ann Rheum Dis |
Individual patient data meta-analysis on continued use of glucocorticoids after their initiation as bridging therapy in patients with rheumatoid arthritis. Based on these RA clinical trial arms with an initial GC bridging schedule, the probability of subsequent ongoing GC use following bridging is low. |
RCT, clinical trials, retrospective studies, etc…
| Arthritis Care Res (Hoboken) |
"Musculoskeletal Ultrasound Enhances the Assessment of Disease Activity in Juvenile Idiopathic Arthritis". Subclinical synovitis was commonly observed in this cohort of JIA patients. The fair to moderate correlation of MSUS synovitis with patient- and provider-reported outcomes suggests that MSUS assesses a different, possibly more objective, domain not determined by traditional JIA outcome measurements. |
Assessing Bleeding Symptoms in Pediatric Patients with Generalized Joint Hypermobility. In a cohort of pediatric patients with GJH, three-quarters of participants had abnormal bleeding scores with mean bleeding score significantly elevated compared to healthy controls. We propose that screening for bleeding symptoms be integrated into routine care for GJH patients, with referral to hematology for patients with bleeding concerns. |
Association of symptoms of gastroesophageal reflux, esophageal dilation and progression of systemic sclerosis-related interstitial lung disease. Severity of reflux symptoms as measured by an SSc-specific questionnaire was independently associated with the change in the radiographic extent of ILD and fibrosis over two years in patients with SSc-ILD. Two objective measures of esophageal dilation were not associated with radiographic progression of ILD, highlighting the need for improved objective measures of esophageal dysfunction in SSc. |
Association of Traumatic Knee Injury with Radiographic Evidence of Knee Osteoarthritis in Military Officers. At the midpoint of a projected 20-year military career, officers with a history of traumatic knee injury have a markedly increased prevalence of knee rOA compared to officers without injury. |
Clinical Characterization of Juvenile Fibromyalgia in a Multi-Center Cohort of Adolescents Enrolled in the FIT Teens Trial. JFM is characterized by chronic widespread pain with fatigue, nonrestorative sleep, and other somatic symptoms. However, how diffusely pain is distributed appears less important to clinical outcomes and impairment than other somatic and psychological factors highlighting the need for a broader approach to the assessment and treatment of JFM. |
Perceived Stress Independently Predicts Worse Disease Activity and Symptoms in a Multi-Racial/Ethnic Systemic Lupus Cohort. In a racially diverse sample of persons with SLE, those who experienced an increase in stress had significantly worse disease activity and greater symptom burden at follow-up compared to those with stress levels that remained stable or declined. Findings underscore the need for interventions to bolster stress resilience and support effective coping strategies among individuals living with lupus. |
| Arthritis Res Ther |
Augmented PFKFB3-mediated glycolysis by interferon- PFKFB3-mediated glycolysis promotes IFN- |
circ-Iqsec1 induces bone marrow-derived mesenchymal stem cell (BMSC) osteogenic differentiation through the miR-187-3p/Satb2 signaling pathway. Taken together, our study found that circ-Iqsec1 induced BMSC osteogenic differentiation through the miR-187-3p/Satb2 signaling pathway. |
Higher fasting blood glucose worsens knee symptoms in patients with radiographic knee osteoarthritis and comorbid central sensitization: an Iwaki cohort study. In patients with radiographic KOA and CS, higher blood glucose levels were associated with deteriorated knee symptoms during the 1-year follow-up. Healthcare providers should pay attention to controlling blood glucose, particularly in patients with KOA and concurrent CS, to mitigate their knee symptoms. Study design Retrospective cohort study (evidence level III). |
HSPB5 suppresses renal inflammation and protects lupus-prone NZB/W F1 mice from severe renal damage. HSPB5 treatment reduces kidney inflammation and injury, providing therapeutic benefits in NZB/W F1 mice. Given that HSPB5 enhances the anti-inflammatory effects of methylprednisolone, there is a strong interest to develop HSBP5 as a therapeutic for the treatment of LN. |
Low disease activity of microscopic polyangiitis in patients with anti-myosin light chain 6 antibody that disrupts actin rearrangement necessary for neutrophil extracellular trap formation. Collective findings suggested that anti-MYL6 antibody disrupted actin rearrangement necessary for NET formation and could reduce the disease activity of MPA. |
Outcome of adult patients with JIA treated with the biosimilar Benepali®: results of the biologic register JuMBO. Tolerability and effectiveness of the biosimilar Benepali ® were satisfactory and therapy survival was comparable to the originator. Further data on therapy with biologics and biosimilars such as Benepali ® must be collected by registries such as BiKeR and JuMBO in order to optimize therapy and patient outcomes and to reduce costs in the health system in the long term. |
| Arthritis Rheumatol |
Activation of a Latent Epitope Causing Differential Binding of Anti-Neutrophil Cytoplasmic Antibodies to Proteinase 3. The preferential binding of PR3-ANCAs from patients like the selective binding of moANCA518 to iHm5 is conferred by increased antigenicity of Epitope 3 on iHm5. This can also be induced on iPR3 when captured by monoclonal antibody MCPR-2. This previously unrecognized characteristic of PR3-ANCA interactions with its target antigen has implications for studying antibody-mediated autoimmune diseases, understanding of variable performance characteristics of immunoassays and design of potential novel treatment approaches. |
Criteria for hyperinflammation developing in coronavirus disease-19: analysis of two cohorts from different periods of the pandemic. The new criteria are expected to define patients with HIC better with reasonable sensitivity and specificity and enable us to start treatment as early as possible. |
Efficacy and Safety of ABBV-3373, a Novel Anti-Tumor Necrosis Factor Glucocorticoid Receptor Modulator Antibody Drug Conjugate, in Adults with Moderate to Severe Rheumatoid Arthritis Despite Methotrexate Therapy: a Randomized, Double-Blind, Active-Controlled Proof-of-Concept Phase 2a Trial. Data from this proof-of-concept trial support the continued development of a TNF-GRM-ADC for the treatment of RA, with the potential to achieve superior outcomes compared to currently available therapies. |
HLA-DPB1 is associated with ANCA-associated vasculitis in children. Similar to previous findings in adult AAV, we found that the HLA-DPB1 locus is associated with pediatric AAV. Despite the difference in the age of onset, these findings suggest that childhood- and adult-onset vasculitis share a common genetic predisposition. The identification of genetic variants contributing to AAV is an important step to improved classification tools and treatment strategies. |
I These results suggest that IKKe regulates cartilage degradation through a catabolic response mediated by NF- |
Independent osteoarthritis risk-conferring alleles mediate the same epigenetic and transcriptional effect on a shared target gene, COLGALT2. COLGALT2 is a target of this OA locus. We previously characterised another OA locus, marked by rs11583641, that independently targets COLGALT2. rs1046934, like rs11583641, mediates its effect by modulating expression of COLGALT2 via methylation changes to CpGs located in enhancers. The SNPs, CpGs and enhancers are distinct between the loci but the effect on COLGALT2 is the same. COLGALT2 is the target of independent OA risk loci sharing a common mechanism of action. |
Interactions Between Genetic Risk and Diet Influencing Risk of Incident Female Gout: Discovery and Replication Analysis of Four Prospective Cohorts. The deleterious effect of genetic predisposition on risk of incident female gout was more pronounced among women with unhealthy diet, with nearly half the excess risk attributable to this gene-diet interaction. These data elucidate the important synergy of genetics and diet for female gout development. |
Knee alignment correction by high tibial osteotomy reduces symptoms and synovial inflammation in knee osteoarthritis accompanied by macrophage phenotypic change from M1 to M2. Correction of lower-limb alignment with HTO attenuated synovial inflammation and changed macrophage polarization from M1 to M2, suggesting an improved intra-articular environment of knee OA. |
Maturity of circulating antibody-secreting cells is associated with disease features in primary Sjögren's syndrome. Numbers and maturation stage of ASCs in pSS patients are increased and correlate with disease parameters. A higher maturity index of ASCs marks a pro-survival and pro-inflammatory phenotype. Altogether, B cell hyperactivity in pSS extends to the peripheral ASC compartment raising potential for ASCs as future biomarker or target for pSS treatment. |
NLRP3 attenuates intraocular inflammation by inhibiting AIM2 mediated pyroptosis through the P-SIK1/SREBF1 pathway. Our data show that NLRP3 inhibits AIM2 inflammasome mediated EAU by regulating the P-SIK1/SREBF1 pathway, highlighting the therapeutic potential of targeting Nlrp3. |
Protein profiling in pre-symptomatic individuals separates MPO-ANCA and PR3-ANCA vasculitides. To our knowledge, this is the first study to identify protein markers preceding symptom onset in AAV. These findings set the stage for further research into underlying cellular and molecular mechanisms in AAV pathogenesis and the diversification into the PR3-ANCA and MPO-ANCA sub-phenotypes. |
The Role of Genetics in Clinically Suspect Arthralgia and Rheumatoid Arthritis Development: A Large Cross-Sectional Study. We observed that genetic predisposition increased across pre-RA participant groups. The RA PRS differed in early classified RA and inflammatory pre-disease stages, regardless of ACPA stratification. HLA-SE prevalence differed between arthritis patients, particularly ACPA+ patients, and healthy controls. Genetics seem to fulfill different etiologic roles. |
| Rheumatology (Oxford) |
A machine learning approach reveals features related to clinicians' diagnosis of clinically relevant knee osteoarthritis. Random forest models presented good performance in explaining clinicians' diagnosis, which helped to reveal typical features of patients recognized as clinically relevant knee OA by clinicians from two different care settings. |
Controversies in Rheumatology: Telemedicine-friend or foe? In this article, the opportunities and threats of telemedicine in rheumatology are debated. A possible way forward is to complement traditional face-to-face visits with information gained by telemedicine, in order to render these consultations more efficient rather than replacing personal contact by technology. |
Determinants of health-related quality of life across the spectrum of connective tissue diseases using latent profile analysis: Results from the LEAP cohort. Distinct HR-QoL subgroups exist that are not primarily driven by the specific diagnosis or autoantibody profiles. We identified a number of key demographic and clinical factors associated with poor HR-QoL. These factors need to be addressed across the whole CTD spectrum as part of a holistic management approach aimed at improving overall patient outcomes. |
Efficacy of subcutaneous vs intravenous infliximab in rheumatoid arthritis: a post-hoc analysis of a randomised phase III trial. IFX s.c. showed improved efficacy at W30 compared with IFX i.v., and the reduced between-group difference in efficacy outcomes at W54 after switching supports the results suggesting benefits of IFX s.c. compared the IFX i.v. at W30. |
Patients' and parents' satisfaction to improve patient care in JIA: factors determining acceptable symptom state measured with JAMAR. Our data highlight the importance of patients' and parents' opinion in the evaluation of disease activity and support their integration into the shared decision-making in daily clinical practice to improve the quality of medical care. |
Serum IFNa2 levels are associated with disease activity and outperform IFN-I gene signature in a longitudinal childhood-onset SLE cohort. Serum IFNa2 levels measured by Simoa technology are associated with disease activity scores and characterize disease activity states in cSLE. |
Plenty of the editorials are available as full text through the publisher website using the provided link
| Ann Rheum Dis |
Novel aspects in the pathophysiology and diagnosis of glomerular diseases. Novel therapeutic approaches aim to mitigate these changes more efficiently and rapidly. Several new agents, such as avacopan, an oral C5aR1 inhibitor, or imlifidase, that dissolves IgG within minutes, are more specifically reducing inflammatory cascades in the kidney and repeat tissue sampling might help to understand their impact on immune cell deposition and finally kidney function recovery and potential impact of immune complexes/deposits. |
| Arthritis Res Ther |
Artificial intelligence and the future of radiographic scoring in rheumatoid arthritis: a viewpoint. Current work in the area demonstrates the feasibility of automating scoring but is yet to take full advantage of the strengths of artificial intelligence. By fully leveraging the power of artificial intelligence, faster and more sensitive scoring could enable the ongoing development of effective treatments for patients with rheumatoid arthritis. |
misc publications eg case reports, tools of the trade, images of the month, etc…
| Arthritis Res Ther |
| Arthritis Rheumatol |
| Rheumatology (Oxford) |
Letters to the editors and authors’ replies
| Arthritis Care Res (Hoboken) |